Zoledronate treatment in active Paget's disease

Pagets Disease Of The Nipple

Pagets disease of uncertain origin: case report

BACKGROUND Pagets disease of the nipple presents as an eczematous lesion, occurs in 1 - 4% of all female breast carcinoma cases and is invariably associated with underlying malignancy either overt or occult. The majority of these cases are invasive disease although 40-45% are associated with DCIS. CASE PRESENTATION A 39 year old lady presented to our unit with a palpable lump in the right bre...

99mTc-MIBI scan in mammary Pagets disease: a case report.

Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) uptake is known to be increased in breast cancer because of increased blood flow from angiogenesis and heightened metabolism. We performed a 99mTc-MIBI scan in a patient with mammary Paget's disease. The patient had underlying invasive cancer in the same side of the breast. 99mTc-MIBI scan exhibited a scintigraphic image of the uptake from t...

Towards Defining a Role for Zoledronate as a Disease- Modifying Treatment in Osteoarthritis: an in Vitro Study of the Effects of Zoledronate on Cartilage and Chondrocyte Proteoglycan Metabolism

Osteoarthritis (OA) is a common group of disabling joint disorders for which there are limited pharmacological therapies to alter disease progression. Zoledronate, one of several bisphosphonates found to modulate joint changes in animal OA models, may have a disease-modifying role, and potential mechanisms of action include effects on cartilage and/or subchondral bone. In OA cartilage, loss of ...

Orbital inflammatory disease after intravenous infusion of zoledronate for treatment of metastatic renal cell carcinoma.

Town,SouthAfrica(DrC.L.Shields); Mellon Charitable Giving from the Martha W. Rogers Charitable Trust, Philadelphia, Pennsylvania (Dr C. L. Shields); the LuEsther Mertz Retina ResearchFoundation,NewYork,New York (Dr C. L. Shields); a donation from Michael, Bruce, and Ellen Ratner, New York (Drs C. L. Shields and J.A.Shields); theEyeTumorResearch Foundation, Philadelphia (Drs C. L. ShieldsandJ.A....